APOE Polymorphisms Contribute to Reduced Atorvastatin Response in Chilean Amerindian Subjects
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چکیده
منابع مشابه
APOE Polymorphisms Contribute to Reduced Atorvastatin Response in Chilean Amerindian Subjects
Genetic factors can determine the high variability observed in response to lipid-lowering therapy with statins. Nonetheless, the frequency of single nucleotide polymorphisms (SNPs) and their impact can vary due to ethnicity. Because the Chilean population carries a strong Amerindian background, the objective of this study was to evaluate the influence of apolipoprotein E (APOE) variants (rs4293...
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BACKGROUND Statins are effective agents in the primary and secondary prevention of cardiovascular disease, but treatment response to statins varies among individuals. We analyzed multiple genetic polymorphisms and assessed pharmacokinetic and lipid-lowering responses after atorvastatin 80 mg treatment in healthy Korean individuals. METHODS Atorvastatin 80 mg was given to 50 healthy Korean mal...
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ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2015
ISSN: 1422-0067
DOI: 10.3390/ijms16047890